Journal of Nutrition & Food Sciences
Open Access

Possible nutritional intervention of sickle cell diseases

International Conference and Exhibition on Nutritional Science & Therapy

August 27-29, 2012 DoubleTree by Hilton Philadelphia, USA

S. Tsuyoshi Ohnishi

Scientific Tracks Abstracts: J Nutr Food Sci

Abstract :

When bloods from patients of sickle-cell disease (SCD) are deoxygenated in vitro, they sickle in a maple-leaf shape, but they do not form a sickle-shape cell. Nobody had paid attention to this phenomenon. We thought it was strange and studied about this carefully. Our findings were: (1) when we exposed the cells to 10 to 20 cycles of ?dexoy-oxy cyclings?, nicely sickled cells were formed (2) When sickled cells were formed, the density of the cells increased by the Gardos effect (Calcium++-activated potassium+ efflux) (3) Using this method, we have shown that the formation of dense-cells was accelerated by the reactive oxygen species (ROS). This suggests that ROS scavengers may be used for nutritional intervention of preventing sickle-cell crises (4) If we repeated the cycling in the absence of an air-water interface, they formed only dense cells, but not the saickled cells