Journal of Clinical & Experimental Dermatology Research
Open Access

The role and relationship of plasma d-dimer level and autologous serum skin test in the chronic spontaneous urticaria

19^th World Dermatology Congress

May 07-08, 2018 Tokyo, Japan

Kwang Joong Kim

Hallym University Sacred Heart Hospital, Republic of Korea

Scientific Tracks Abstracts: J Clin Exp Dermatol Res

Abstract :

Background: It has been reported that the severity of Chronic Urticaria (CU) may be associated with D-dimer level, and patients with CU often have other autoimmune disorders, including autoimmune thyroid disease. Autologous Serum Skin Test (ASST) is thought to identify autoimmune/autoreactive disease in patients with CU. Objective: The aim of this study was to evaluate whether D-dimer, total Immunoglobin E (IgE), and autoimmune markers, such as Anti-Thyroid Peroxidase (TPO) and Anti-Thyroglobulin (TG), were elevated in ASST-positive patients with CU compared to ASST-negative patients, and whether these laboratory findings were related to the severity of CU. Methods: Fifty-four adults with CU were recruited (16 ASST-positive, 38 ASST-negative). D-dimer, total IgE, autoimmune markers (anti-TPO and anti-TG), thyroid hormone levels, and Urticaria Activity Score (UAS) were measured. Results: Serum D-dimer level was not significantly different between the ASST-positive and ASST-negative groups. Additionally, total IgE, anti-TPO, anti-TG, and thyroid function tests showed no difference according to ASST response. UAS was higher in the ASST-positive compared to ASST-negative group, but the ASST-positive group showed better response to treatment. Patients with CU with elevated D-dimer level had high UAS compared to those with normal D-dimer level. Total IgE was related to UAS only in the ASST-negative group, and anti-TPO and anti-TG were not related to UAS. Conclusion: Laboratory findings, including serum D-dimer, total IgE, autoimmune markers, and thyroid function tests, were not linked to ASST response. UAS was higher in patients with CU with elevated D-dimer level, and total IgE level was related to UAS in the ASST-negative group. The ASST-positive group showed high UAS compared to the ASST-negative group, but showed better response to treatment. Therefore, ASST response, D-dimer level, and total IGE are potential predictors for CU severity.

Biography :

Kwang Joong Kim is currently working in Hallym University Sacred Heart Hospital in Republic of Korea. He is doing research in Chronic urticaria, Autologous serum skin test.
Email:hallymdermaa@naver.com