Organic Chemistry: Current Research
Open Access

Recent progress in green solid-phase peptide synthesis (GSPPS)

4^th European Organic Chemistry Congress

March 01-03, 2018 | London, UK

Ayman El-Faham, Yahya E Jad, Ashish Kumar, Gerardo A Acosta, Beatriz G de la Torre and Fernando Albericio

King Saud University, Saudi Arabia
Catalysis and Peptide Research Unit - University of Kwazulu-Natal, South Africa
Institute for Research in Biomedicine, Spain
Alexandria University, Egypt
University of Barcelona, Spain

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Dimethylformamide (DMF) along with dichloromethane (DCM) has been widely used as solvent in SPPS. However, these chemicals are hazardous and new strategies have been employed to substitute them by green solvents. During the last years, our group has started a program constantly been working in this area of research. Herein we reported the use of 2-Methyltetrahydrofuran (2-MeTHF), cyclopentylmethyl ether (CPME), tetrahydrofuran (THF), N-formylmorpholine, 2-Methyltetrahydrofuran (2-MeTHF), isosorbide dimethyl ether, ethylacetate, �±-valerolactone and �±,�±,�±-trifluorotoluene as greener alternative solvents in peptide synthesis as well as Fmoc-removal. The ability of these solvents for swelling of polystyrene and polyethylene glycol resins were evaluated. In addition, racemization and coupling efficiencies were evaluated with a model of peptides, such as Aib-enkephalin pentapeptide and Aib-ACP decapeptide, in combination with polyethylene glycol ChemMatrix resin and polystyrene (PS) resin. aelfaham@ksu.edu.sa