Journal of Clinical Toxicology
Open Access

Redox regulation in health and disease: Novel hypothesis

6^th Global Summit on Toxicology & Applied Pharmacology

October 17-19, 2016 Houston, USA

Xin Wang, Xiaodi Zhang and Chunxu Hai

Fourth Military Medical University, China

Posters & Accepted Abstracts: J Clinic Toxicol

Abstract :

In view of the critical role of redox system in numerous physiological and pathophysiological processes, it is important to clearly understand the constitution and regulatory mechanism of redox system. In this work, we will systematically review the current data detailing the reactive oxygen species (ROS), enzymatic and non-enzymatic antioxidants and redox sensitive transcription factors and we give a brief description of redox-exerted epigenetic and post-translational regulation. We propose that the redox system functions as a â�?�?Redox Chainâ�?, consisting of â�?�?ROS-generating Enzyme Chainâ�?, â�?�?Combined Antioxidant Chainâ�? and â�?�?Transcription Factor Chainâ�?. We suggest that redoxomic techniques should be extensively applied to understand the biological effects of redox alterations in a more integrated way. A stable and standardized â�?�?redox indexâ�? is urgently needed for the evaluation of the general redox status. We suggest that for the redox intervention of an individual, an individualized assessment of the redox status in the body should be conducted. The strategy of intervention is to maintain general redox balance rather than to conduct simple pro-oxidant or anti-oxidative interventions. These findings provide valuable new insights into redox system and open up new paths for the control of redox-related disorders.

Biography :

Email: xinwang@fmmu.edu.cn