Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Lu Xiulan
Hunan Children�s Hospital, China
Posters & Accepted Abstracts: Pediatr Ther
Aim: To analyze the relationship between beta cell dysfunction and severity of disease in critically ill children. Methods: 1146 critically ill children admitted in PICU of Hunan Childrenâ��s Hospital from November 2011 to August 2013 were studied which were divided into group-1 (HOMA-�²â�¥100%, n=339), group-2 (80%â�¤HOMA-�²â�¤100%, n=71), group-3 (80%â�¤HOMA-�²â�¤40%, n=293), group-4 (HOMA-�²<40%, n=443). Results: Incidence of HOMA-�²<100% was 70.41%. C-peptide and insulin level showed a falling trend with worsening HOMA-�² (P<0.01), C peptide and insulin was positively related with HOMA-beta (rs1=0.443, rs2=0.443, P<0.01), positive correlation between insulin and C peptide (rs3=0.601, P<0.01). Th e WBC level did not diff er in four groups (P>0.05); the diff erence of CRP and PCT levels among groups were signifi cant (P<0.01). Th e worst SOFA score in group-1, 2, 3 and 4 was 1.55�±1.85, 1.71�±1.93, 1.92�±1.63 and 2.18�±1.77 (P<0.05). Incidence of septic shock in Group-4 was highest (7.22%), incidence of MODS in group-2 was highest (21.12%, rate of MV in group-2 was highest (32.39%), mortality in group-1, 2, 3, 4 was 7.08%, 12.67%, 5.12% and 12.67%. Incidence of septic shock, MODS, mechanical ventilation and mortality in four groups had Statistical signifi cance (P<0.05). Conclusions: Beta cell dysfunction existed in PICU, which to some extent refl ects the severity of disease in critically ill children.
Lu Xiulan has completed her MD from Xiangya Medical College, Central South University. She is currently the Director of Emergency Center of Hunan Children's Hospital. She has published more than 20 papers in reputed journals in China and has been serving as an Editorial Board Member of repute.