Pediatrics & Therapeutics
Open Access

Relationship between hepcidin, L-carnitine, anemia and inflammation in children of hemodialysis

5^th International Conference on Pediatric Nursing & Healthcare

July 11-12, 2016 Cologne, Germany

Gamila S M El-Saeed

National Research Centre, Egypt

Scientific Tracks Abstracts: Pediat Therapeut

Abstract :

Background: The majority of studies on anemia, inflammation, and disturbances of iron metabolism have focused on patients in end-stage renal failure; this study aim was to investigate the relationship between Carnitine and Hepcidin levels among the children of hemodialysis end stage renal disease (ESRD) and iron metabolism in them. Method: Thirty children with ESRD undergoing HD, and thirty healthy, age- and sex-matched children were included. Serum levels of iron, ferritin and total binding capacity (TIBC), hemoglobin, albumin (ALB). Total L-Carnitine (LC), high-sensitivity C-reactive protein (hs CRP), hepcidin were measured. Result: Abnormal serum inflammatory changes iron status and LC , were exhibited in HD children compared with healthy controls, Pearson�s correlation revealed a significant inverse correlation between hepcidin levels and ferritin, and positively with hs CRP and iron where serum albumin positively with hsCRP and ferritin , also a positive correlation found between LC and iron, ferritin. A multivariate regression analysis demonstrated a positive correlation between inflammatory risk marker hs CRP >3 mg/l) and hepcidin levels. Also a positive correlation was found between LC and iron levels. Conclusion: In children under hemodialysis, oral L-carnitine can increase serum albumin level and prevent CRP rising, beneficial effects of L-carnitine on anemia and, its supplementation is recommended for these patients. Malnutritioninflammation complex is an incremental predictor in hemodialysis patients. Further studies are needed to assess whether modulating inflammatory or nutritional processes can improve anemia management.

Biography :

Gamila S.M.El-Saeed has completed her M.D from Medical University in Basic Science and Biochemistry from Cairo College, Egypt. She has published more than 30 papers in international journals. She is a professor of Medical Biochemistry in National Research Centre, Egypt.

Email: ggamilaa@yahoo.com