Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Maria Monette S Ong-Misa, Robert Dennis J Garcia, Mercy Jeane Uy-Aragon and Mary Ann Arkoncel-Adapon
Makati Medical Center, Philippines
Posters & Accepted Abstracts: Pediatr Ther
Background & Objectives: Immature Platelet Fraction (IPF) is a new hematologic parameter which refl ects the rate of thrombopoiesis. Th is study aims to determine the relationship between IPF and platelet count among pediatric patients with thrombocytopenia due to dengue fever. Methods: Th is was a prospective cross-sectional study of 77 pediatric dengue patients admitted at a private hospital in the Philippines. Baseline and daily IPF, platelet count, hematocrit, white blood cells count (WBC) and presence of fever was recorded according to day of illness. Th e pattern of IPF in relation to the patterns of platelet count, hematocrit, WBC count and fever were analyzed. Th e proportion of patients showing platelet recovery at diff erent time points and an IPF cut-off value predictive of platelet recovery within 24 hours was also determined. Results: Th e IPF increased as the platelet count decreased. Th e highest increase in IPF coincided with the trough of platelet count. 87% of the patients showed platelet recovery aft er the increasing trend of IPF, 87% aft er the peak value and 95% aft er the decreasing trend. An IPF value of more than 6.6% was predictive of platelet recovery with a sensitivity of 45% and specifi city of 70%. Conclusion: Th ere was an inverse relationship between IPF and platelet count but with a statistically indirect and weak correlation. Th e decreasing trend of IPF can be a good predictor of an increasing trend in platelet count. Th ese fi ndings suggest a possible role of IPF as an additional parameter to predict platelet recovery in dengue fever. mariamonette@yahoo.com Pediatr Ther 2017, 7:3 (Suppl) DOI: 10.4172/2161-0665-C1-043 Are fertility and its preservation discussed with girls undergoing treatment for cancer? Philippa Ball University of Cambridge, UK Ovarian cryopreservation is an up-and-coming fertility preservation technique. Th e process involves laparoscopically removing slices of ovary and cryopreserving these sections, with a view to auto-transplant back to the patient at a later date. Ovarian cryopreservation has already seen success in women of reproductive age; we now look to determine how it can be used in the context of pediatric oncology. Previously, girls and their parents had very limited options regarding the oft endevastating eff ects of cancer treatment on their reproductive health. Many chemotherapies and radiotherapy have the potential to cause premature ovarian failure, resulting in infertility. Studies have shown that patient and parent groups see infertility as one of the most signifi cant late eff ects of treatment, so something must be done to address both these concerns and the real risk of sterilizing treatment. Th erefore, the project explored to what extent a regional center is considering the late eff ect of infertility in pediatric cancer patients. We assessed to what extent oncologists are discussing fertility issues and whether ovarian cryopreservation is being advocated for young girls with cancer. Based on our fi ndings, we suggest improvements for how we can better advocate patient�s best interests in the topic of onco-fertility.