Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-77-2385-9429
ISSN: 2167-0501
+44-77-2385-9429
Flaszka E, Baudoux V, Larroze-Chicot P, Meunier J, Cazavieille C, Cosnier-Pucheu S,Roman F and Gonzalez-Gonzalez S
CILcare, France
Amylgen, France
Bio Nano NMRI, University of Montpellier. France
Posters & Accepted Abstracts: Biochem Pharmacol (Los Angel)
Melatonin is a hormone produced by the pineal gland in animals that regulates sleep and wakefulness. It is involved in
the circadian rhythms synchronization including sleep-wake timing, blood pressure regulation, seasonal reproduction,
etc. However, other physiological roles have been described for melatonin such as antioxidant protection of nuclear and
mitochondrial DNA, anti-inflammatory effect by TNF-�± inhibition, etc. Because increasing number of studies demonstrated
that antioxidants may serve as effective compounds to block cochlear inflammation and hair cells apoptosis, targeting members
of antioxidant pathways could be feasible options for the treatment of several types of hearing loss. For this reason, the aim of
this study is to determine the effect of melatonin in the hearing impairment and anxiety induced by acoustic trauma.
Recent Publications
1. Casteil, et al. (2017) Study of the efficacy of melatonin for auditory brainstem response (ABR) testing in children.
European Annals of Otorhinolaryngology, Head and Neck Diseases 134.
2. Tao, et al. (2009) Protective effect of melatonin against gentamicin ototoxicity. The Journal of Laryngology & Otology
123:598�602.
3. Bas, et al. (2009) An experimental copmparative study of dexamethasone, melatonin and tacrolimus in noise-induced
hearing loss. Acta Oto-Laryngologica 129:385�389.
4. Lopez-Gonzalez, et al. (2000) Ototoxicity caused by aminoglycosides is ameliorated by melatonin without interfering
with the antibiotic capacity of the drugs. J. Pineal Res. 28:26�33.
5. Lopez-Gonzalez, et al. (1997) Presence of the pineal hormone melatonin in rat cochlea its variations with lighting
conditions. Neuroscience Letters 238:81�83.
Elodie demonstrates an excellent level of technical skills in fields including neurosurgery, general surgery, and behavioral tests. A graduate in analytical and experimental biology, she has been working for 5 years on the development of drug candidates in neurosciences. For CILcare, she specializes in the in-vivo models of ear inflammation, and carries out efficacy studies, as well as other tasks, from designing protocols to interpreting discovery data, with great talent and dynamism
E-mail: elodie.flaszka@cilcare.com