Journal of Clinical and Cellular Immunology
Open Access

Role of the innate immune elements in the chronic inflammatory diseases

International Conference on Innate Immunity

July 20-21, 2015 Barcelona, Spain

Silvia Vidal

Posters-Accepted Abstracts: J Clin Cell Immunol

Abstract :

This lecture will be focused on the interaction of multiple elements in the innate immune response of chronic inflammation patients: soluble mediators, cellular receptors and cells. The first point will be the expression of the TLRs on cells of the innate immune system, including the impact of TLR-induced signals on the cellular migration and scavenger properties of monocytes/macrophages. The second point will be the modulation of the epigenome by TLR-induced signals. Both points will be addressed at the steady state conditions of healthy donors as well as chronic inflammation in certain pathologies (inflammatory bowel disease, rheumatoid arthritis). The lecture will include the discussion about factors affecting the TLRinduced signals that can contribute to the inflammatory pathology and novel therapies oriented to regulate these factors. The audience of this lecture will see the development of the first stage of translational research in chronic inflammation using patient samples with a variety of innovative methodology in a multidisciplinary team.