Endocrinology & Metabolic Syndrome
Open Access

RSRC1 sumoylation regulates the sumoylation and transcriptional activity of estrogen receptor-β

3^rd International Conference on Endocrinology

November 02-04, 2015 Atlanta, USA

Long Cheng

Beijing Institute of Biotechnology, China

Posters-Accepted Abstracts: Endocrinol Metab Syndr

Abstract :

The transcription factor estrogen receptor �² (ER�²) plays a role in the central nervous, endocrine, cardiovascular and immune systems. ER�² can be sumoylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ER�² and sumoylation of RSRC1 is required for regulation of PIAS1-mediated ER�² sumoylation. RSRC1 promotes ER�² sumoylation through enhanced interaction between ER�² and PIAS1. RSRC1 represses ER�² transcriptional activity through regulation of ER�² sumoylation. By establishing RSRC1 as a novel co-factor for sumoylation, our data provide insight into regulation of ER�² sumoylation and indicate that sumoylation of one protein can regulate another protein sumoylation.

Biography :

Email:

flonic@163.com