ISSN: 2161-1017
+44 1478 350008
Long Cheng
Beijing Institute of Biotechnology, China
Posters-Accepted Abstracts: Endocrinol Metab Syndr
The transcription factor estrogen receptor �?² (ER�?²) plays a role in the central nervous, endocrine, cardiovascular and immune systems. ER�?² can be sumoylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ER�?² and sumoylation of RSRC1 is required for regulation of PIAS1-mediated ER�?² sumoylation. RSRC1 promotes ER�?² sumoylation through enhanced interaction between ER�?² and PIAS1. RSRC1 represses ER�?² transcriptional activity through regulation of ER�?² sumoylation. By establishing RSRC1 as a novel co-factor for sumoylation, our data provide insight into regulation of ER�?² sumoylation and indicate that sumoylation of one protein can regulate another protein sumoylation.
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