Virology & Mycology
Open Access

Serum TNF alpha as a biomarker of Temporal Mesial Epilepsy associated with HHV6/HHV7 neuroinfections in humans

Joint Event 10^th International Virology Summit & 4^th International Conference on Influenza & Zoonotic Diseases

July 02-04, 2018 | Vienna, Austria

Maltsev

Immunology and Molecular Biology Laboratory of Research Institute of Experimental and Clinical Medicine, Ukraine

Scientific Tracks Abstracts: Virol Mycol

Abstract :

According to results another researches in this study mesial temporal lobe epilepsy (MTLE) is shown to be associated with human herpes virus 6 and 7 types (HHV6/HHV7) neuroinfections. We also demonstrate that the epileptic process is associated with an systemic inflammatory reaction, and that the proinflammatory cytokine, the tumor necrosis factor-alpha (TNF-�±), is able to potentiate the reproduction of the herpes viruses. The study group (SG) included 43 patients between 16 and 60 years with MTLE and HHV neuroinfections, diagnosed according to the PCR of the cerebrospinal fluid (CSF), serum or abnormal serum/CSF IgG ratio. The control group (CG) included 30 patients of similar age with MTLE, but without the HHV neuroinfections. The concentration of TNF-�± in the serum was determined by enzyme-linked immunosorbent assay ("VektorBEST" RF; N=0-50 pg/ml). Patients of the SG had high concentrations of TNF-�± in serum (288�±44.7 pg/ml), that were significantly higher than in the CG (p<0.05; Z