Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Alhusain Nagm, Tetsuyoshi Horiuchi and Kazuhiro Hongo
Shinshu University, Japan
Al-Azhar University, Egypt
Posters & Accepted Abstracts: J Clin Exp Cardiology
Introduction: According to our previously reported studies, white matter hyperintensities (WMHs) might decrease following extracranial (EC)-intracranial (IC) bypass. Herein, the efficacy of successful EC-IC bypass in WMHs-course was investigated. Methods: After obtaining the institutional review board approval, perioperative FLAIR-MRIs of 12 patients with WMHs, who underwent bypass surgeries for cerebral ischemia, were enrolled in this study. First, evaluation of regional cerebral blood flow on perioperative 123I-iodoamphetamine single photon emission computed tomography studies was done. Second, FLAIRMRI protocol was defined, scaling evaluation table was designed, regions of interest were determined on a slice-by-slice basis, subjective errors were avoided, and meticulous volumetric grading and visual assessment of WMHs were done by three experienced raters, independently. Then, WMHs-course was determined to be improved (WMHs decreased), fluctuating, worsened (WMHs increased) or stationary. Finally, statistical analysis was done. Results: Decreased WMHs were seen in 41.7% of patients. Most of them (80%) exhibited bilateral improvement despite unilateral bypass surgeries. Also, fluctuating (33.3%), stationary (16.7%) and increased (8.3%) WMHs were documented. Good clinical outcome was not always accompanied with decreased WMHs. Conclusion: An obvious positive effect of EC-IC bypass on WMHs was documented. This study might stimulate future researches to evaluate the reversibility of ischemic WMHs on FLAIR-MRI as a marker for sufficient brain revascularization. nagm@shinshu-u.ac.jp