Journal of Clinical and Cellular Immunology
Open Access

Some biochemical markers that can predict pre-eclampsia

Conference Series LLC Joint International Event on 5^th European Immunology & Innate Immunity

July 21-23, 2016 Berlin, Germany

Mohammad Sayyed Bakheet, Mohamed Ismail Seddik, M H Abdelzaher, Mohammad Mohammad Abolfotoh, Abdelaziz Eldarwesh, Alomairi Mostafa M and Maher Abdelshakor

Al-Azhar University, Egypt
Assuit University, Egypt

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

TNF-���± directly damages the vascular endothelial cells, reduces regional blood flow, causes occlusion of vessels and increases endothelial permeability. Endothelial cell injury after TNF-���± mediated activation of immune system may result in secretion of vasoactive substances and increase in vascular permeability and intravascular coagulation. TNF-���± may be involved in the pathogenesis of preeclampsia and may identify the patients who are at high risk of PE and can be a potential marker of the severity of the preeclampsia syndrome. Women with preeclampsia had deranged lipid profile due to abnormal lipid metabolism; this alteration of lipid metabolism may play a key role in the development of symptoms of Pre-eclampsia. Furthermore, changes to lipid metabolism may contribute towards the endothelial lesions observed in pre-eclampsia.