Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
+44 1300 500008
ISSN: 2376-0419
+44 1300 500008
Syed Hadi Hasan and Titto Sunil John
Indian Institute of Technology, India
Scientific Tracks Abstracts: J Pharma Care Health Sys
Nearly 40% of the new drug entities synthesized by the pharmaceutical industry is mostly insoluble in water. Thus the patients are forced to take drugs in high doses and more frequently to attain the desired bioavailability of the drug. Hence gastrointestinal (GI)solubility is an essential parameter in the development of a new drug. Much research has been done on this field aiming at increasing the kinetic as well as the absolute solubility ofthe drug. Methods like complexation of the drug with hydrophiles /amphiphiles, crystalengineering, and freeze-drying are the significant methods adopted. In addition to these methods, particle size reduction, in particular, synthesis of nanosuspension or nanodispersion of the drug is a very practical and economical method. The particle size is reduced either by milling or by the preparation of nanosuspension. This work focusses onthe preparation and characterization of Nimesulide nanosuspension by high-pressure homogenization ofthe drug-surfactant mixture. Nimesulide is NSAID which works by the inhibition of proinflammatory COX-2 enzymes. The drug has been shown to cause severe liver damage andsometimes death due to its high dosage and residence time in the liver. Nanosuspension of Nimesulide is prepared by combining it with different stabilizers (steric andelectrostatic). The stability of the drug nanosuspension is determined by measuring theagglomeration of the nanoparticle. The size, morphology and homogeneity of the nanosuspension is characterized by electron microscopy.