Journal of Clinical Toxicology
Open Access

Supplementation of dietary amino acids in pig diets to enhance immunity and alleviate deoxynivalenol induced impairments

International Toxicology Summit & Expo

November 26-28, 2012 Hilton San Antonio Airport, USA

Wence Wang, Li Wu, Ting Zhou, Jie Yin, Jie Pan, Ruilin Huang and Yulong Yin

AcceptedAbstracts: J Clinic Toxicol

Abstract :

D eoxynivalenol (DON), a mycotoxin mainly produced by Fusarium graminerum , can inhibit protein synthesis and suppress immunity, resulting in reduced feed intake and poor growth performance. Addition of arginine-family amino acids in feed of piglets may recover immunity of pigs and alleviate the adverse effects of DON on their growth performance. A total of thirty healthy piglets (Landrace×Yorkshire) at 60-d-old were randomly divided into 5 groups. Three of them were assigned amino acid (AA) treatments, and supplemented in their diet with 1.0% Arg (AAa), 1.0% Gln (AAg) and 0.5%Arg+0.5%Gln (AAa+g) respectively. The other groups were set as a toxic control (TC) and a blank control (BC). All piglets had undergone an immune- fortification period of 21 days and then had voluntary feed intake for additional 30 days with final DON concentration at 6 mg/kg. The average daily weight gain (ADWG) in all groups with DON was lower than that in BC group (P<0.0001). However, compared to TC, the average daily feed intakes (ADFI) increased by 6.0, 2.4 and 5.2% in AAa, AAg and AAa+g treatments, respectively (P<0.0001). Liver weights in TC were 13.5% heavier than that in BC (P=0. 0215); the increase in liver weights was not observed in AAa, AAg and AAa+g. Pigs in TC had a significantly lower GH (growth hormone) and IGF (insulin growth factor) values than BC (P<0.001), however, the reduction in GH and IGF values was not found in AAa, AAg and AAa+g. The superoxide dismutase (SOD) in AAa was 46.1% higher than that in TC (P<0.001). In addition, IL-2, haptoglobin and MDA (Malondialdehyde) values of AAa, AAg and AAa+g were much lower than TC (P<0.001). All these indicated that dietary supplementation of amino acids can improve immune health and alleviate metabolic impairment induced by DON stress in piglets

Biography :

Wence Wang is Ph.D student at Institute of Subtropical and Agriculture, the Chinese Academy of Sciences. Now she is in Agriculture and Agri-Food Canada for her mycotoxin detoxification investigation. She had published more than 18 papers and abstracts in reputed journals