Organic Chemistry: Current Research
Open Access

Supramolecularly regulated ligands for asymmetric transformations

International Conference on Organic Chemistry

August 10-11, 2016 Las Vegas, Nevada, USA

Anton Vidal-Ferran

Institute of Chemical Research of Catalonia, Spain
Catalan Institution for Research and Advanced Studies, Spain

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

The design, synthesis, coordination studies and application of enantiopure ligands Lig a-f/x-z with a site that can be regulated through supramolecular interactions will be described. The basic backbone of these catalysts is based on a polyethyleneoxy chain (regulation site) with appended ligating groups at the �?± and Ï�? positions (catalytic site). The regulation mechanism is activated by a regulation agent (RA) which interacts with the regulation site through supramolecular interactions and leads to a particular catalytic system, which preserves the majority of the structural characteristics of the original ligand, but also incorporates geometrical peculiarities in the active site that depend on the regulation agent used. Our approach is inspired in the allosteric regulation mechanism in living systems. Non-natural enantioselective catalysts with a regulation site remain relatively unexplored. The use of this strategy permitted the highly enantioselective hydroformylation of linear and cyclic alkenes, the highly enantioselective hydrogenation of functionalized alkenes,[2b] and allylic substitution reactions.

Biography :

Email:

avidal@iciq.cat