Organic Chemistry: Current Research
Open Access

Synthesis and biological evaluations of new 1,2,4-triazine derivatives as antimalarial agents

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Mpelegeng Victoria Bvumbi

University of Venda, South Africa

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Malaria together with six other diseases (diarrhoea, HIV/AIDS, TB, measles, hepatitis B and pneumonia) account for 85% of global infectious diseases burden and therefore impose great socio-economic burden on humanity. There are drugs in the market which can be used to treat or prevent malaria. The most widely used drugs to treat malaria are quinine and its derivatives as well as antifolate combination drugs. The major obstacle in the treatment of malaria is the drug resistance in malarial parasites and the resistance has been reported for almost all the antimalarial drugs. There is an interesting class of compounds which were promising in the fight against malaria and these are called triazines. Whilst more work has been done and reported on triazine, especially on 1,3,5-triazines class, not much has been done on 1,2,4-triazine as antimalarial agents. Due to their resemblance to the pyrimethamine type of pyrimidine antimalarial, the 3,5-diamino-1,2,4-triazine derivatives are believed to have more activity against strains of Plasmodium Falciparum, hence the starting compound 1. The synthetic approaches towards 2 and 3 and their preliminary biological data will be described in this presentation.