Journal of Clinical Trials
Open Access
ISSN: 2167-0870
ISSN: 2167-0870
Khairujjaman Laskar
Tezpur University, India
Posters & Accepted Abstracts: J Clin Trials
Bioconjugated nanomaterials offer innumerable opportunities to advance both nanobiotechnology and biomedical technology. The goal of bioconjugate chemistry is to develop simple and efficient methods for chemical bonding of biomolecules with other molecules. Both chitosan and unsaturated fatty acid derivatives are described in the literature for their interesting bioactive properties, including anti-cancer activity. Among various forms of chitosan-derivatives, fatty acidchitosans are increasingly being prepared to have the variety of shapes and sizes with enormous applications. Considering the above fact, we have synthesized the undec-10-enoic acid functionalized chitosan-based undecyl-chitosan (U-CS) nanobioconjugate with the use of DCC as a coupling agent. The U-CS conjugate formed was confirmed by FTIR, 1H-NMR and further characterized by TGA, XRD, SEM and TEM analysis. Further, we have evaluated the in-vitro anti-bacterial, and anti-cancer potential of U-CS nano-bioconjugate against human pathogenic bacterial strains (E. coli and L. monocytogene) and human cancer cell lines (HeLa, MDA-MB-231 and Hep3B). The results of our study clearly revealed that U-CS nanobioconjugate showed enhance anti-bacterial, anti-biofilm as well as anti-cancer efficacy as compared to the pure and free form of the chitosan.