Organic Chemistry: Current Research
Open Access

Synthesis and cytotoxicity of palladium, platinum and silver complexes containing oxazolines

Webinar on World Congress on Chemistry and Chemical Technologies

February 09, 2022 | Webinar

Mei Luoa, Jing-Cheng Zhang , Hao Yinc , Cheng-Ming Wang , Lan Xie , Kang-Po Li, Masuo Goto , Susan L. Morris-Natschke , Kuo-Hsiung Leeb , Jia-Hai Zhang, Yan-Min Zhang,Xue-Ru Zhanga

College of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, Peopleâ??s Republic of China.
Natural Products Research Laboratories, UNC Eshelman, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599â??7568, USA.
Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, 230026, China.
Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, 40447, Taiwan.
Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China.
Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China

Scientific Tracks Abstracts: OCCR

Abstract :

Organometallic complexes containing oxazoline ligands, particularly chiral oxazolinyl palladium and platinum complexes can be used as important anticancer reagents in the field of medicine. The purpose of this study is to describe the method of synthisis of six novel chiral organometallic complexes, which from the reaction of different oxazoline ligands [[(R/S)-1,4-R1Ox]2C6H4 (R1: D/L-CH(CH3)2 or D-CH2Ph) and Zn(CyanoBox)2] with PdCl2, Pt(DMSO)2Cl2 or Pt(DMSO)2(NO3)2 in good yields (68-92%): binuclear cyclometalated complex {Pd[(S,S)-1,4-i-PrOx]2C6H4}2Cl4}, 1; Pt(CyanoBox)(DMSO)Cl, 2;{[Pt(R,R)-1,4- phenylOx]2C6H4},3;3{Pt[(R,R)-1,4 phenylOx]2C6H4}212+•PhCOOË?•11NO3Ë?, binuclear cyclometalated complex {Pt[(R,R)-1,4-benzyl]2 C6H4}2•3ClË?• 9NO3Ë?, 4; polymer chains {[Pt(R,R)-1,4-phenylOx]C6H4}•NO3Ë?, 5; and polymeric silver species Zn(CyanoBox)2•AgNO3•CHCl3, 6. Desirablely, the complexes 1–6 showed cytotoxic effects against human tumor cell lines, including a multidrug-resistant subline.

Biography :

Mei Luo was born in 1969 in Bozhou, Anhui Province, P.R.China. She received her B.S. and M.S. degrees in chemistry from Hefei University of Technology and obtained a Ph.D at the University of Science and Technology of China in 2002. She then studied as a postdoctoral fellow at Beijing University. At 2014 and 2017, she further studied as a visiting scholar at the university of Utah and UNC in accordingly. Currently, she is an associate professor at Hefei University of Technology, where her research interests include organic and organometallic chemistry and asymmetric catalysis.