Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Simurova N V, Shulga S I and Shulga O S
National University of Food Technologies, Ukraine
Posters & Accepted Abstracts: Organic Chem Curr Res
Indolo[2,3-b]quinoxalines is formed when indole and quinoxaline fragments combine to form an heterocycle. These heterocyclic systems are interesting for research due to the properties like antiviral, antitoxic activity, as well as powerful intercalators exhibiting cytotoxic and interferon-inducing activity. State of art literature data analysis shows that, acyl or alkyl substituents at the nitrogen atom of the indole fragment is necessary for the manifestation of biological activity. Methods of synthesizing such compounds are complex and not numerous, so the search for new methods is still relevant. We have studied the reaction of alkylisatins and benzoylisatin with 4-methylbenzene-1,2-diamine, which in one stage results in the derivatives of 6H-indolo- [2,3-b] quinoxaline with a substituent at the nitrogen atom of the indole fragment. We have found that, the condensation of alkyl and benzoylisatins with 4-methylbenzene-1,2-diamine in glacial acetic acid which proceeds stereo-selectively results in the formation of 3-methyl-6R-indolo [2,3-b] quinoxalines. Hence, by the methyl group oxidation previously unknown indolo [2,3-b] quinoxaline carbaldehydes have been received, and by the nitro group reduction - the corresponding indoloquinoxaline amines were obtained.
Simurova N V is an Associate Professor in Organic Chemistry department, National University of Food Technologies of Ukraine. She has previously worked as a Synthetic Organic Chemist at the Institute of Organic Chemistry of the National Academy of Sciences of Ukraine. She is the author of over 50 scientific publications and textbooks on organic synthesis of medicines.
Email: n.v.simurova@gmail.com