Organic Chemistry: Current Research
Open Access

Synthesis and use of nitroxides (aminoxyl radicals) in biochemistry and medicine

International Conference on Organic Chemistry

August 10-11, 2016 Las Vegas, Nevada, USA

Lawrence J Berliner

University of Denver, USA

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Aminoxyl radicals (aka nitroxides) have been developed and applied since the 1960s where a lot of the initial synthetic work was carried out in the USSR at the Institute of Chemical Physics. It was quickly picked up at Stanford as the primary stable radical probe for the biochemical technique of spin labeling. While the three-electron bond N-O radical was actually quite stable to fairly harsh chemical treatment, it was initially pegged as a carcinogen by the na�¯ve biology-medical establishment, probably after the initial work of Commoner and others on their work with reactive oxygen species and cancer, hypoxia, etc. However, as we shall discuss today, these compounds have just the opposite effects and are now being commercially sold as cardioprotective agents, antitumor and antiaging agents as well as enhancing memory and quality of life aspects. They are also useful as imaging and contrast agents for diagnostic therapy. This talk covers a brief history, aspects of synthesis, oxidationreduction behavior, biological applications and therapeutic applications. It is hoped that the general synthetic methodology and oxidation-reduction properties may stimulate other synthetic chemists to devise other compounds utilizing functional groups not yet envisioned.

Biography :

Email: lawrence.berliner@gmail.com