Organic Chemistry: Current Research
Open Access

Synthesis of 9,10-phenanthrenes via palladium-catalyzed aryne annulation by o-halostyrenes and formal synthesis of (±)-tylophorine

International Conference on Organic Chemistry

August 10-11, 2016 Las Vegas, Nevada, USA

Tuanli Yao

Shaanxi University of Science and Technology, China

Scientific Tracks Abstracts: Organic Chem Curr Res

Abstract :

Phenanthrenes are valuable skeletons found in numerous biologically active natural products and medicinal compounds. They are also a common structural motif in material science because of their unique photochemical and electroluminescent properties. A novel palladium-catalyzed annulation reaction of in situ generated arynes and o-halostyrenes has been developed, which affords moderate to excellent yields of substituted phenanthrenes and tolerate a variety of functional groups such as nitrile, ester, amide, and ketone. This annulation chemistry has been successfully applied to the formal total synthesis of a biologically active alkaloid (�±)-tylophorine.

Biography :

Tuanli Yao has completed his PhD from Iowa State University and Post-doctoral studies from University of California, Berkeley. He worked as a Senior Scientist at Deciphera Pharmaceuticals and Associate Researcher at University of Kansas before beginning his career in academics. Currently, he is a Professor at Shaanxi University of Science and Technology. His research interests include aryne chemistry, electrophilic cyclization and palladium catalysis. He has published more than 30 papers in reputed journals.

Email: yaotuanli@sust.edu.cn