Organic Chemistry: Current Research
Open Access

Synthesis of new structures of imidazolium salts

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Eyad Mazin Mallah

University of Petra, Jordan

Scientific Tracks Abstracts: Organic Chem Curr Res

Abstract :

As result of the strongly basic character of heterocyclic carbenes 1, they react with Broenstedt acids and have consequently been used as selective deprotonation reagents. The 2H-imidazolium salts formed by this method are accessible by other routes, alkylation of 2H-imidazoles, cyclization reactions from the thiones and nitric acid, and may be used as precursors in the synthesis of 1 through deprotonation. So our current research efforts also continue to focus on design and synthesis of new structures of imidazolium salts. Therefore, owing the strongly basic character of heterocyclic carbenes reacted with methyl phenyl disulfide to give the corresponding adduct 2 which afford a new synthetic route for 2, 3-dihydro-imidazole-2-thione. While, the reaction of 1 with bis-methane sulfone was carried out at RT to give the salt. The mentioned reactions are outlined in scheme 1, the results confirmed by NMR, mass spectroscopy, elemental analysis and single crystal X-ray diffraction.

Biography :

Eyad Mazin Mallah has completed his PhD at Tuebingen University, Germany. He is currently working as an Associate Professor and Dean’s Assistant in the Faculty of Pharmacy at the University of Petra. He has a specific interest in Pharmaceutical Organic Chemistry and Pharmaceutical Analytical Chemistry. Currently, he is working on development of chromatographic and immunoassay methods for analyzing different pharmaceutical compounds in biological fluids which could be used in bio-studies. In addition, he is interested in drug-drug interactions and drug-juice interactions which could affect the pharmacokinetic profile of some pharmaceutical products. He is also working on the synthesis of some Barbituric acid and Imidazole derivatives and their application in pharmaceutical compounds. He has published about 50 articles in different international journals.