Drug Designing: Open Access
Open Access

Targeting the Notch signaling pathways of hepatocarcinoma and glioblastoma multiform using ultra small iron oxide nanoparticles conjugated gamma secretase inhibitor

International Conference and Expo on Drug Discovery & Designing

August 11-13, 2015 Frankfurt, Germany

Anamaria Orza

Posters-Accepted Abstracts: Drug Des

Abstract :

Recent developments in cancer biology have identified the existence of a sub-population of cells—cancer stem cells—that are
immune to most traditional therapies (e.g., chemotherapy and radiotherapy) and have the ability to repair their damaged DNA.
Here, we show the resistance of hepatocarcinoma stem cells and glioblastoma multiform stem cells to both radiation and therapy.
Also, we show the efficiency of the conjugated iron oxide nanoparticles for the in vivo disruption of Notch signaling by the gamma
secretase inhibitor DAPT [N-(N-((3,5-Difluorophenacetyl))-L-alanyl)-S-phenylglycerin t-butyl ester. By introducing these targeted
conjugated nanoparticles, detection, targeting, and destruction of the Hepatocarcinoma and glioblastoma stem cells was achieved. An
efficient alternative treatment for the incurable disease of cancer could be provided.