Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Yaping Tian, Xueliang Huanga and Chunyan Zhang
Chinese PLA General Hospital, China
Scientific Tracks Abstracts: J Clin Exp Cardiolog
The cardiovascular disease (CVD), which includes acute coronary syndrome (ACS) and heart failure (HF), is the global leading cause of human death. The blood biomarkers, as targets of treatment, will help to prevent and treat CVD. They could aid in early prognosis and diagnosis of CVD and effectively reduce the morbidity and mortality, which is the focus in research for CVD. This study aimed to screen effective blood markers for different stages of CVD. We have detected 11 amino acids and SA in HC and patients with MS, ACS and HF. GLY and PRO were significant difference between the AMI and the UAP. The ROC curve area of them in multivariate analysis was 0.681 (0.600-0.754) (p<0.001). ARG, GLY, MET, TYR and SA were significant difference between the AMI and the MS. The ROC curve area of GLY and ARG in multivariate analysis was 0.953 (0.911-0.979) (p<0.001). There were significant differences in 9 amino acids and SA between the AMI and the HC. The ROC curve area of GLY, ORN and PHE in multivariate analysis was 0.991 (0.962-0.999) (p<0.001). There were significant differences in 3 parameters between the CHF and the UAP. The ROC curve area of CIT and L-I-P in multivariate analysis was 0.839 (0.742-0.910) (p<0.001). Eleven blood amino acids and SA in patients with MS, ACS and CHF and in HC have been analyzed and the variation between groups have been found, the results suggested that branched chain amino acids and aromatic amino acids may be biomarkers for CVD.
Yaping Tian is the Professor and Director of TRANSLATIONAL MEDICINE LABORATORY, Chinese PLA General Hospital. He received his Master’s Degree in Medicine from Chinese PLA Postgraduate Medical School and PhD from Academy of Military Medical Sciences in 1993. He had been trained as Postdoctoral Fellow for 2 years(1995-1997) in The Queen Elizabeth Hospital, Australia. He has has been focusing on the study of the specific serum proteomic profiles and genetic signatures in different diseases, especially on cancer and cardiovascular diseases. He also has received more than 20 grants and published more than 400 scientific papers in peer-reviewed journals.
E-mail: tianyp@301hospital.com.cn