Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
+44 1478 350008
ISSN: 2155-9554
+44 1478 350008
Anna Barilo, S V Smirnova and M V Smolnikova
Scientific Research Institute of Medical Problems of the North, Russia
Posters & Accepted Abstracts: J Clin Exp Dermatol Res
Introduction: Psoriasis (PS) is one of the most common widely spread skin diseases. One of the most severe forms of psoriasis is psoriatic arthritis (PsA) that belongs to the chronical progressive inflammatory joints diseases. The important role in pathogenesis of psoriasis and psoriatic arthritis plays the hepatobiliary system pathology. Therefore, study of the liver and biliary tract pathology in psoriasis and psoriatic arthritis is an urgent task. Purpose: To characterize features of the functional state of the hepatobiliary system in psoriasis and psoriatic arthritis in order to reveal the markers of disease progression. Methods: The study included patients with psoriasis (n=49), psoriatic arthritis (n=48) and practically healthy blood donors (control, n=35). We used laboratory and instrumental study methods which reflect the functional state of the hepatobiliary system. Statistical analysis was performed by non-parametric Mann-Whitney test. Results: The results showed common features of psoriasis and psoriatic arthritis compared to control, statistically significant increased levels of total bilirubin, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, decreased level of triglycerides, higher prevalence of ductal and diffuse liver changes, gallbladder wall thickening by ultrasound. This study also found the features of PsA that were not common for PS and compared to control, increased levels of cholesterol and low density lipoprotein, hepatomegaly. Conclusion: Our data indicate that the liver and the biliary tract are one of the main target organs in psoriasis and psoriatic arthritis. The markers of psoriasis are diffuse liver changes and chronic cholecystitis. The marker of psoriatic arthritis is nonalcoholic fatty liver disease.
Email: anntomsk@yandex.ru