Journal of Clinical and Cellular Immunology
Open Access

The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion

Conference Series LLC Joint International Event on 5^th European Immunology & Innate Immunity

July 21-23, 2016 Berlin, Germany

Jae Seung Kang, Seyeon Bae, Keunhee Oh, Yejin Kim, Hang-rae Kim, Young-il Hwang, Dongsup Lee and Wang Jae Lee

Seoul National University, South Korea

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Alloferon is a novel immunomodulatory peptide originally isolated from infected insects. It has anti-viral and anti-tumor effects via the activation of NK cells. However, specific mechanisms leading to NK cell activation and anti-tumor responses yet to be clarified. In this study, we demonstrate that alloferon increases killing activity of NK cells to cancer cells via the up-regulation of the expression of NK-activating receptors, 2B4. In addition, the production of IFN-���³ and TNF-���± and granule exocytosis from NK cells against cancer cell were increased by alloferon. Lastly, the anti-tumor effect of alloferon was confirmed in vivo to demonstrate effective retardation of tumor growth in the human to mouse xenograft model. All taken together, these results suggest that alloferon has antitumor effects through up-regulation of NK-activating receptor 2B4 and the enhancement of granule exocytosis from NK cells.