Endocrinology & Metabolic Syndrome
Open Access

The effect of over nutrition on Skeletal development

2^nd International Conference on Endocrinology

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Efrat Monsonego Ornan

Accepted Abstracts: Endocrinol Metab Synd

Abstract :

Childhood obesity is a serious global public health problem, reaching 40% of children in developed countries. While the connection between under-nutrition and growth retardation is well documented, the opposite connection between overnutrition and bone development was barely studied. Obese children grow faster in height than normal-weighed children, and prospective studies demonstrated an over-presentation of obese children amongst fracture cases. Yet, the cellular and molecular underlying mechanisms to this phenomenon are largely unknown. We analyzed in depth the effect of childhood obesity on young bone elongation and bone quality. Multiple complementary in-vivo models were utilized to characterize in details the growth-plate phenotype as well as the bone structure and mechanical properties. The various models we used are: pharmaceutical inhibition of leptin signaling (by leptin antagonists) and various types of obesogenic diets such as high fat diet (HFD). We found that obesity in young age affected both bone elongation and bone quality. Furthermore, the type of the diet, distinctly from its obesogenic effect, modified bone development and quality. For instance, while HFD based on poly unsaturated fatty acids impairs bone morphology; omega-3 fatty acids improves it. Our studies demonstrated the involvement of metabolic signals such as adiponectin, leptin and IL1. We discovered a novel mechanism by which osteocalcin shifts chondrocytes toward glycolytic breakdown of glucose and stimulates their calcification, in a HIF-1α-dependent manner. Based on these findings, we suggest that the metabolic status in obesity and the specific component in the diet affect directly the metabolic state of bone cells, leading to accelerated bone elongation and modified processes of bone formation and resorption. This topic is of tremendous importance for both basic and applicative scientists in the fields of pediatrics, nutrition, endocrinology, bone health and development.

Biography :

Efrat Monsonego-Ornan has completed her PhD. At the Hebrew University of Jerusalem and postdoctoral studies in Weizmann institute in Israel. She is a professor at the department of Biochemistry and nutrition, and more than 40 papers in reputed journals and serving as an editorial board member of PlosOne. The broad aim of her research is to understand the role of nutritional and metabolic factors in bone development.