Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
+44 1223 790975
ISSN: 2329-8901
+44 1223 790975
Omima Abdelgader Mohammed
Accepted Abstracts: J Prob Health
The probiotics are live microorganisms, have multiple mechanisms of action that could disrupt the pathogenesis of HE and may make them superior to conventional treatment. Objectives: To study the effect of using probiotics on the outcome of hepatic encephalopathy in cirrhotic patients in Ibn-Sina hospital, Khartoum, Sudan, 2012 Methodology: This is a randomized case-control hospital-based trial study conducted between case group (35 patients) named A and control group (35 patients) named B. Group A received probiotane in addition to the classical treatment, while group B received classical treatment only. All patients were evaluated before and after receiving probiotics by grading of HE , child Pugh classification and psychometrics test. The data collected subjected to analysis by SPSS program, results presented as tables and graphs. Results: It was found that, the age group 41-50 years was the most common; 24 (34.3%). In group A, male and female ratio was 6:1, while in group B male to female ratio was 2.5:1. HE grade 0 appeared in 15 (42.9%) patients in cases group (A) versus 9 (25.7%) in the control group (B) after use of probiotic, grade I in 10 (28.6%) patients in cases group (A) versus 11 (31.4%) in the control group (B), grade II in 4 (11.4%) patients in case group (A) versus 5 (14.3%) in the control group (B), grade III in 1 (2.9%) patient in case group (A) versus 6 (17.1%) in the control group (B), while in grade IV 5 (14.3%) in case group (A) versus 4 (11.4%) in control group (B), (P=0.238). Child Pugh classification of liver cirrhoses after probiotic treatment show that, 8 (24.2%) patients in case group (A) versus 3 (8.6%) in the control group (B) had grade A, 22 (62.9%) patients in case group (A) versus 24 (68.6%) in the control group (B) had grade B, while 3 (9.1%) patients in case group (A) versus 8 (22.96%) in the control group (B) had grade C. Psychometric test was performed after the probiotic treatment for the study groups, showed that 15 (42.9%) patients in case group (A) versus 10 (28.6%) in the control group (B) had normal figure connected test, while 20 (57.1%) patients in case group (A) versus 25 (71.4%) in the control group (B) had abnormal figure connected test (P=0.212). Conclusion: Although the evaluation of the effect of probiotics in patients with hepatic encephalopathy statistical was not significant, normalization of psychometric test and improvement in grade I & II in addition to improvement in child Pugh classification was seen among patients of case group probiotics are safe, natural and well tolerate therapy.