Journal of Clinical & Experimental Dermatology Research
Open Access

The role of selenium, deficiency and toxicology in dermatology

7^th European Dermatology Congress

June 13-14, 2016 Alicante, Spain

Lyly Nazemi

Tehran University of Medical Sciences, Iran

Posters & Accepted Abstracts: Clin Exp Dermatol Res

Abstract :

Many nutrients such as macronutrients and micronutrients (selenium) are essential for life. Adequate amount of these nutrients in our diet is necessary for providing energy, various metabolic processes, building and maintaining body organs. Selenium is an antioxidant mineral responsible for tissue elasticity. It also acts to prevent cell damage by free radicals. Many researches demonstrated the photo-protective potential of antioxidants, such as selenium and the effects of micronutrient supplementation on the skin immune system. Selenium is an essential constituent of enzyme glutathione peroxide which in the presence of reduced glutathion, breaks down, potentially damaging the reactive peroxides. Associated skin signs include hypopigmentation of the skin and hair and whitening of the nails. Since it can protect the skin from damage of excessive UV light; but, over time, high doses of selenium can be toxic. In this condition, side effects include: Fingernail loss, skin rash, fatigue, irritability, weight loss. As of now, selenium toxicity is diagnosed based upon the presence of features of selenosis in humans, since there is no accurate biochemical or preclinical parameters. Airborne exposure is rare, but occupational exposure is possible with the chemical processes for recovery of selenium, painting trades and the metal industries. Acute selenium toxicity may presents with acute respiratory distress syndrome, myocardial infarction, renal failure and vascular symptoms such as tachycardia and flushing of the face, such as T-wave inversion and QT prolongation are often seen and death is due to refractory hypotension.

Biography :

Email: nazemile@tums.ac.ir