Organic Chemistry: Current Research
Open Access

The versatile biocatalyst-Candida parapsilosis ATCC 7330

2^nd International Conference on Past and Present Research Systems of Green Chemistry

September 14-16, 2015 Orlando, USA

Anju Chadha

Indian Institute of Technology Madras, India

Posters-Accepted Abstracts: Organic Chem Curr Res

Abstract :

Biocatalysis, an important �green� component of sustainable chemistry, primarily, implies the use of enzymes in synthetic organic chemistry. It has been projected that the industry method of synthesizing 20% of the global production of non-natural chemicals by 2020 will employ biocatalyst- mediated reactions. The use of whole cells of Candida parapsilosis ATCC 7330 has been effectively used by us to generate a variety of optically pure sec. alcohols and amines by deracemisation and asymmetric reduction, which have also been used as chiral synthons in a larger synthetic scheme. This yeast has been shown to oxidise primary and sec. alcohols and also has acylase activity. All these results in high ee [up to 99%] and yields [up to 85%]. Parallely, we have crystallised a carbonyl reductase from the Candida in order to understand the enantioselectivity of the enzyme at the molecular level. The talk will summarize our results.

Biography :

Email: anjuc@iitm.ac.in