Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
A P Malyshkin
Accepted Abstracts: J Clin Cell Immunol
Studies on computer simulation of the genome leads to understanding of not only the characteristics of body elements (structure, weight, color, etc.), but also all interactions between them are directly determined at the genomic level. Tolerance of self-antigens should also be directly determined by the genome, through genomic or "smart" recognition, rather than through negative selection against self-reactive lymphocytes. The concept of linked functions holds that the very presence of the genes of class I MHC self-antigens in the genome "automatically" precludes immune response to these antigens. Therefore, integration of certain class I MHC genes of the donor into the genome of the recipient's hematopoietic stem cells in the course of preoperative treatment should result in tolerance of the donor's MHC antigens. Conceivably, this approach to the formation of tolerance should also work for xenogenic grafts, which would considerably enhance the possibilities of tissue and organ transplantation. The technique for integrating foreign class I MHC genes into the genome of hematopoietic stem cells has not been developed thus far. Solution of the numerous problems involved requires experimental research.
Alexander P. Malyshkin, male, microbiologist, graduated from Orenburg State Medical Academy in 1979 and worked for this academy as a researcher. After defending his Candidate of Science (Med.) dissertation (PhD thesis), he headed the Division of Laboratory Diagnosis of Orenburg Regional Tuberculosis Dispensary for some time. Dr. Malyshkin's field of research includes microbiology, immunology, and issues of infectious diseases and their prevention. He is the author of the active susceptibility hypothesis and a fundamentally new approach to the prevention of infectious diseases of plants, animals, and humans (including the HIV infection) based on it. The main recent work (now in press) is the chapter on the prevention of infectious diseases in the book Aquatic Plants and Plant Diseases (to be published by Nova Science). Dr. Malyshkin is exploring the possibility of collaboration in further developing and implementing his novel approach to disease prevention, which could be used, in particular, for breeding infection-resistant animal and plant varieties.