Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Alaa Fouad Ali, Sherein S AbdEl-Gayed, Osama S EL-Tawil and Adel M Bakeer
Cairo University, Egypt
Posters & Accepted Abstracts: J Clinic Toxicol
Tartrazine is organic azo dyes food additives widely used in foods, drugs, and cosmetic. The present study aimed to investigate the toxic effects of tartrazine on kidney and liver biomarkers in addition to investigation of oxidative stress and change of histopathological structure of liver and kidneys in thirty male rats. Tartrazine was orally administrated daily at dose 200mg/ kg bw (1/ 10 LD50) for sixty days. Serum and tissue samples were collected at the end of the experiment to investigate the underlying mechanism of tartrazine through assessment oxidative stress (GSH, SOD, and MDA) and biochemical markers (ALT, AST, Total protein and Urea). Liver and kidneys tissue were collected and preserved in 10% formalin for histopathological examination. The present study indicates that sub-chronic effects of tartrazine not only cause changes in hepatic and renal parameters but also it can induce oxidative stress by formation of free radicals in addition to histopathological changes in liver and kidney.
Email: alaafouad303@yahoo.com