Journal of Medical Diagnostic Methods
Open Access
ISSN: 2168-9784
+44 1300 500008
ISSN: 2168-9784
+44 1300 500008
Wang Yi1, He Du2, Yang Liang3, Wen Bo1, Dai Jinfen4, Zhang Qian2, Kang Jian4, He Weiyang2, Ding Qianshan4 and He De1
1Southern Medical University Affiliated Shenzhen Baoan Hospital, China
2Wuhan University, China
3Qianjiang Central Hospital, China
4Renmin Hospital of Wuhan University, China
ScientificTracks Abstracts-Workshop: J Med Diagn Meth
Hepatocellular carcinoma (HCC) is the one of the most common malignancies worldwide and its prognosis is extremely poor. Tripartite motif (TRIM) proteins play crucial roles in cancer cell biology but the function of tripartite motif 26 (TRIM26) has not been investigated. We demonstrated that low expression level of TRIM26 in tumor samples was significantly correlated with worse prognosis in HCC patients. We also demonstrated its expression level was associated with several clinicopathologic features such as AFP level and T stage of HCC patients. Furthermore, we validated that TRIM26 was significantly down regulated in HCC tissue compared with normal liver tissue. To further clarify the functional role of TRIM26 in HCC, we confirmed that TRIM26 silencing will promote cancer cell proliferation, colony forming, migration and invasion in vitro with HCC cell lines HepG2 and Bel-7402. Then we utilized bio-informatic tool to predict gene influenced by TRIM26, showing TRIM26 could modulate gene sets about cancer cell metabolism. In conclusion, we prove that TRIM26 is a novel tumor suppressor modulating multiple metabolism related pathways in HCC. To our best knowledge, this is the first study to investigate the function of TRIM26 in cancer biology. Our findings provide useful insight into the mechanism of HCC origin and progression and TRIM26 may represent a novel therapeutic target for HCC.
Email: wangyichenben@163.com