Immunome Research
Open Access

Type 1 Diabetes: Prediction and progression

International Conference on Autoimmunity

October 13-14, 2016 Manchester, UK

K M Gillespie, A E Long, I Wilson, D J Becker, I M Libman, F S Wong, A K Steck, M J Rewers, P Achenbach and A J K Williams

University of Cambridge, UK

Scientific Tracks Abstracts: Immunome Res

Abstract :

Multiple islet autoimmunity increases risk of diabetes but not all individuals positive for two or more islet autoantibodies progress to disease within a decade. The SNAIL study seeks to harmonize data from longitudinal studies to identify the characteristics of slow progression to type-1 diabetes. Samples from 125 individuals with multiple islet autoantibodies (IAA, GADA, IA-2A and ZnT8A) for more than 10 years without progression were available from four studies (Bart-Oxford (BOX), UK; BABYDIAB, Germany; DAISY and Pittsburgh Diabetes, USA). Individuals enrolled in BOX provided â�?�?Rapid Progressorâ�? (diagnosed

Biography :

K M Gillespie is a Molecular Biologist with a long term interest in the genetic mechanisms underlying autoimmunity. She has joined the Diabetes and Metabolism Unit in 1998 as a Non-Clinical Lecturer having worked previously as a Post-doctoral Researcher at the Academic Renal Unit in Bristol and at the Department of Medicine, University of Cambridge. Her current research projects include further analysis of the novel observation that maternal cells have the capacity to differentiate into functional pancreatic beta cells, studies into the role of NK cells in autoimmune diabetes and the immunogenetic characterization of Diabetes in Down’s Syndrome. She has research interests in autoimmunity, genetic mechanisms, maternal cells, functional pancreatic beta cells, NK cells, autoimmune diabetes and diabetes.

Email: K.M.Gillespie@bristol.ac.uk