Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Arnold Emerson Isaac
Vellore Institute of Technology University, India
Scientific Tracks Abstracts: J Proteomics Bioinform
Network studies are becoming an upcoming trend of interest across numerous disciplines as they are being used to analyze biological systems such as protein interactions, metabolic pathways, gene regulatory mechanisms and also protein contact networks. Network modeling of protein structures help us understand the architectural design of proteins and have many implications to the structure and function. The present research is an attempt to analyze network properties within transmembrane and globular proteins wherein we found that it possessed small world properties in comparison with random networks. Findings revealed that central residues in protein structures were conserved and were slowly evolving. To demonstrate core-periphery hierarchical organization, k-core decomposition technique was applied to protein contact networks and interestingly we found that residues belonging to the innermost cores played a critical role in the function or structural stability of the protein. On analyzing the network properties of the Domain Co-occurrence Networks (DCN�s) of H. sapiens, M. musculus, D. melanogastor, C. elegans and S. cerevisiae findings suggested that central domain patterns among the five species were preserved through evolution. Cancer mutations and domain co-occurrence networks provided a framework for understanding hierarchal designs in protein function from a network perspective. This implies that a majority of protein domains in the inner core of the DCN have a lower mutation frequency and that protein domains present in the peripheral regions of the k-core contribute more heavily to the disease. These findings propose important directions to further drug development.
Arnold Emerson Isaac received his PhD from the School of Bio Sciences and Technology at the VIT University, India. He obtained his Post-doctoral studies at the Weill Cornel Medical College, Qatar. He is currently an associate professor at the VIT University and has eleven years of experience in teaching and academic research.
Email: i_arnoldemerson@yahoo.com