Organic Chemistry: Current Research
Open Access

Uses of cyclohexan-1,3-dione for the synthesis of heteroccyclic compounds together with their cytotoxic evaluations

10^th European Organic Chemistry Congress

March 21-22, 2019 | Rome, Italy

Rafat M. Mohareb

Cairo University, Egypt

Posters & Accepted Abstracts: Organic Chem Curr Res

Abstract :

Thienopyridines (4,5,6,7-tetrahydrothieno[3,2-c]pyridines) and their derivatives are important heterocyclic compounds that are of great interest. Many of the compounds containing tetrahydro thienopyridine skeleton are reported as antibacterial, non-peptide GPIIb/IIIa antagonists, platelet aggregators and antithrombotic agents. The incorporation of benzylic or substituted benzylic groups on the nitrogen of the thienopyridine ring can bring an extensive structural modification in the biological activities of parent compound. Among the substitutions occurred at nitrogen of the thienopyridine moiety, the increased effect in the biological activity of the parent moiety affects the good antithrombotic activity in Ticlopidine and with more increased activity in Clopidogrel. Later on, the studies proved that the Prasugrel to be high efficient drug candidate than the existing Clopidogrel by making change in structure of the parent thienopyridine moiety. Hence, the presence of different substitutions at nitrogen of the thienopyridine moiety may bring extensive improvement in the biological activity of the new chemical entities (NCEs). To avoid the cancer disease novel molecules are urgently required, because the pharmacological fight against this disease has made significant progress in the last twenty years. Due to the biological importance, efforts are considered in this context as we synthesized a series of thienopyridine derivatives together with studying their cytotoxic evaluations, c-Met kinase inhibition and the most potent compounds were investigated as Pim-1 kinase inhibitors.