Journal of Clinical and Cellular Immunology
Open Access

Viral cooption and amplification of pro-inflammatory and IFN mediated reprogramming of macrophage’s metabolism

Conference Series LLC Joint International Event on 5^th European Immunology & Innate Immunity

July 21-23, 2016 Berlin, Germany

Konstantinos Kotzamanis

University of Edinburgh, UK

Posters & Accepted Abstracts: J Clin Cell Immunol

Abstract :

Viruses are obligatory parasites that both exploit and counter selective host pathways, including metabolism, to effectively propagate. Recent studies from our group and others have revealed a central connection between infection and metabolism in regulating the host response. In particular macrophages, among other immune cells, reprogram and tightly regulate their metabolism upon activation from IFN and/or TLRs. Here, we employ transcriptomics and metabolomics analyses of wild type and mutant Cytomegalovirus infection of wild type and IFNB-/- or IFNAR-/- macrophages. These investigations enable the unraveling of host directed versus virus driven responses and we find unexpectedly that Cytomegalovirus opportunistically coopts early pro-inflammatory changes in glycolysis for establishing infection of macrophages.

Biography :

Konstantinos Kotzamanis has completed his Bachelor’s studies in Chemistry/Biochemistry at the Aristotle University of Thessaloniki. He was awarded a scholarship from IKY/EU (Greek State Scholarship Foundation) for his MSc at the University of Edinburgh, which he received in 2012. He was, in addition, awarded a scholarship from IKY/EU and the University of Edinburgh for his PhD studies in the lab of Professor Peter Ghazal. He has one publication and has been awarded a prize for best poster at the BSI summer school in 2014.