Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
+44 1300 500008
ISSN: 1948-5964
+44 1300 500008
Jia Ning, Gao Yan, SUO Jijiang, XIE Li-jun, YAN Zhongqiang, XING Yu-bin and LIU Yun-xi
Scientific Tracks Abstracts: JAA
The aim of this study was to determined the viral shedding of the young adult patients with mild 2009 H1N1 infl uenza in China. From Sep 2009 to Jan 2010, the clinical data and serial nasopharyngeal swabs of 67 patients with 2009 H1N1 infl uenza and 37 patients with seasonal infl uenza aged from 18 to 35 years old were collected. Th e nasopharyngeal swab samples were detected by Real Time RT-PCR to determine the viral shedding. All the patients were not given antiviral therapy but Chinese medicine for detoxicating. Among the patients with H1N1 virus infection, 82.1% (55/67) patients presented with fever symptom, but more patients with high fever(≥39°C) were found in seasonal infl uenza patients (P<0.05). For the H1N1 patients, the median interval between the symptom onset and the undetectable RNA was six days (4 ~10d). But viral shedding was still found in 31.3% patients aft er 7 days following illness onset. Th e median interval between disappearance of fever and an undetectable viral RNA level was three days (2~8d), and 17.9% patients were found to be viral shedding 6 days later aft er normalization of body temperature. For the seasonal infl uenza patients, 94.6% patients were detected out viral RNA within 7 days. Th e median interval of seasonal infl uenza between the symptom onset and the undetectable RNA was four days ( 3-8d). Th e median interval between disappearance of fever and an undetectable viral RNA level was three days (2~6d). It suggests that 7 days isolation period from the illness onset or 24 hours aft er the resolution of fever and respiratory symptoms are not long enough to cut off the transmission among Chinese young adults with mild illness.