Current Synthetic and Systems Biology
Open Access

Xenobiotic responses and synthetic biology

2^nd International Conference on Systems & Synthetic Biology

August 18-20, 2016 London, UK

Taosheng Chen

St. Jude Children�s Research Hospital, USA

Posters & Accepted Abstracts: Curr Synthetic Sys Biol

Abstract :

Xenobiotic receptor pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics to regulate the expression of drug metabolizing enzymes and transporters. Xenobiotics that are known to activate PXR and trigger xenobiotic responses include synthetic chemicals and synthetic peptides. Since activation of PXR might lead to clinical drug-drug interaction, it is critical to investigate the xenobiotic responses and design strategy to minimize the undesired impact of synthetic materials on drug metabolism. By using a chemical biology approach we have developed modulators of PXR that will be useful for modulating xenobiotic responses triggered by synthetic materials.

Biography :

Email: taosheng.chen@stjude.org