Journal of Drug Metabolism & Toxicology
Open Access

Cytochrome 450 Drug Metabolism

Cytochromes P450 (CYPs) belong to the superfamily of proteins containing a heme cofactor and, therefore, are hemoproteins. CYPs use a variety of small and large molecules as substrates in enzymatic reactions. CYPs are the major enzymes involved in drug metabolism,most drugs undergo deactivation by CYPs, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYPs to form their active compounds.

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