Journal of Drug Metabolism & Toxicology
Open Access

Drugs metabolised by CYP2D6

CYP2D6 gene encoded in humans for the enzyme Cytochrome P450 2D6.It is expressed in the liver and in areas of CNS. It is responsible for the metabolism and elimination of approximately 25% of clinically used drugs, in a process referred to as O-demethylation. This enzyme also metabolizes several endogenous substances such as hydroxytryptamines and neurosteroids.

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