Journal of Applied Pharmacy
Open Access

de la Torre Iglesias PM

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• Research Article
  New Multi-Particle Systems for Colon-Targeted Meloxicam
  Author(s): Eva Navarro Ruiz, Covadonga Álvarez Álvarez, Juan J García Rodriguez, Santiago Torrado Durán, Susana Torrado Durán and de la Torre Iglesias PM Eva Navarro Ruiz, Covadonga Álvarez Álvarez, Juan J García Rodriguez, Santiago Torrado Durán, Susana Torrado Durán and de la Torre Iglesias PM
  
  Meloxicam (MLX) is a non-steroidal anti-inflammatory drug (NSAIDs) from the Oxicam family. This group of NSAIDs has been highly used in the treatment of rheumatoid arthritis and post-operative inflammation and is known as good antioxidants. Recently, their activity in chemoprevention, chemo-suppression, UV-sensitization and UVprotection was also identified. MLX has been described as a COX-2 selective inhibitor. Its use has some advantages regarding to its selectivity, namely, less adverse effects as gastrointestinal aggression and anticlotting activity. As MLX is better absorbed in colon and its properties against colon cancer and colonic inflammatory diseases are being studied, it is interesting to investigate a new MLX formulation for colonic delivery. We are studying the solubility and the dissolution of different combined formulations at pH 1.2, 6.8 and 7.4 to mimic their absorban.. View More»
  DOI: 10.21065/1920-4159.1000221

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