Pancreatic Disorders & Therapy
Open Access

Marion Piechotta

Publications

• Research Article
  Pancreatic Exocrine Insufficiency Affects Not Only Digestibility of Nutrients and Growth, but Also Body Composition and Endocrinological Parameters- Study on Piglets Used As a Model for Children
  
  Author(s): Anne Mößeler, Teresa Schwarzmaier, Peter Colin Gregory, Marion Piechotta, Martin Beyerbach and Josef KamphuesAnne Mößeler, Teresa Schwarzmaier, Peter Colin Gregory, Marion Piechotta, Martin Beyerbach and Josef Kamphues
  
  The pancreatic duct ligated (PL) piglet is a model for pancreatic exocrine insufficiency (PEI) in children. PEI is very common in children suffering from cystic fibrosis and is of highest relevance as the nutritional status affects survival rate of these patients. This study aimed comparing growth and body weight development of PL-piglets with (PL+enz) or without (PL-0) pancreatic enzyme replacement therapy (PERT) with those of controls. Growth, proportion of gastrointestinal tract (GIT; including digesta) and digestibility of nutrients was measured in young PL-pigs. The body weight (kg) at dissection differed significantly (p<0.005) between controls (79.7), PL-0 (51.3) and PL+enz (62.9). GIT mass accounted for 8.17% of body weight in controls, 21.1% in PL-0, whereas in PL+enz the relative weight of GIT was 12.0% differing significantly (p<0.01) from both other groups. Faecal di.. View More»
  DOI: 10.4172/2165-7092.S5-003

  Abstract

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