Pancreatic Disorders & Therapy
Open Access

Shin Takasawa

Publications

• Review Article
  Intermittent Hypoxia in Pancreatic beta Cells
  Author(s): Hiroyo Ota, Shin Takasawa, Motoo Yamauchi, Masanori Yoshikawa, Koichi Tomoda and Hiroshi Kimura Hiroyo Ota, Shin Takasawa, Motoo Yamauchi, Masanori Yoshikawa, Koichi Tomoda and Hiroshi Kimura
  
  Sleep apnea syndrome (SAS) a highly prevalent disorder, and characterized by repetitive episodes of intermittent hypoxia (IH), i.e. recurrent episodes of oxygen desaturation during sleep, the development of daytime sleepiness, and deterioration in the quality of life. Multiple epidemiological studies have provided evidence implicating the presence of SAS as a risk factor for insulin resistance and type 2 diabetes and have reported that type 2 diabetes is associated with SAS independently of age, sex, and body habitus. One of the postulated mechanisms for the metabolic alterations associated with SAS is that IH leads to substantial alterations in both pancreatic β cell function and organ glucose homeostasis. On the other hand, hyperglycemia is known to increase the rate of β cell replication, which can provide an increased source of insulin to combat insulin resistance. Altho.. View More»
  DOI: 10.4172/2165-7092.S5-004

  Abstract PDF

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