Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
ISSN: 2736-6588
Department of Neurosurgery, Sun Yat-Sen University, Guangzhou, China
Research Article
Analysis of Integrating PIK3CA and NF1 Mutations into Glioblastoma Multiforme Prognostication and Immunotherapy Treatment Strategy
Author(s): Lin Xie*, Anmin Liu*, Qinbiao Chen, Min Luo, Linlin Lu, Wenjing Lin and Cheng Zhong
Objective: The potential mechanisms of NF1, Phosphatidylinositol-4,5-bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) and Neurofibromatosis 1 (NF1) expressions in Glioblastoma Multiforme (GBM) have been poorly elucidated. Risk-score analysis combined with clinic pathological characteristics to assess the prognostic value and immunotherapy efficacy of 6-genes signature.
Methods: We performed the whole exosome sequencing profiling on samples form patients with GBM. The association of PIK3CA and NF1 expression within the GBM have received cross-validations by Mendelian Randomization (MR) methods and the risk-score analysis of 6-gene signature.
Results: MR study demonstrated that PIK3CA and NF1 expressions were closely related with the risk of GBM patient.. View More»
DOI:
10.35248/2736- 6588.24.7.287