Angiology: Open Access
Open Access

Department of Cardiology, State Key Laboratory of Frigid Zone Cardiovascular Diseases, General Hospital of Northern Theater Command, Liaoning Province, China

Publications

• Research Article   
  Oral Soluble Guanylate Cyclase Stimulators in Heart Failure: A Meta-Analysis of Randomized Controlled Trials
  Author(s): Qiang Ren, Quanyu Zhang* and Sicong Ma*
  
  Background: The impact of Guanylate Cyclase (sGC) stimulators on clinical outcomes of HF patients were still controversial. Objectives: To investigate the efficacy and safety of oral soluble sGC stimulators in Heart Failure (HF). Methods: PubMed, Web of Science, and Cochrane Library were searched to identify Randomized Controlled Trials (RCTs) comparing sGC stimulators vs placebo in HF patients. A total of 6 RCTs with 7382 HF patients were included. Results: Compared with placebo, oral sGC stimulators reduced the risk of a composite of Cardiovascular (CV) death or Hospitalization for HF (HHF), Odd’s Ratio (OR) 0.87, 95% Confidence Interval (CI) 0.78-0.98, p=0.02), and CV death [OR 0.45, 95% CI 0.38-0.53, p<0.001]. Significant reduction in the CV death [OR 0.42, 95% .. View More»
  

  Abstract PDF