Lupus: Open Access
Open Access

Divaker Choubey

Biography

Dr. Choubey’s current research interests include the role of the interferon (IFN)-inducible Ifi200-family genes in the development of autoimmunity, inflammation, and associated diseases. The family includes structurally and functionally-related murine and human genes. The murine genes (Ifi202a, Ifi202b, Ifi203, Mndal, and Aim2 etc.) form a cluster, which is located between the Spna-1 and the Sap loci on the long-arm of the Chromosome 1. The human genes (IFI16, MNDA, IFIX, and AIM2) are located in the syntenic 1q22 region. Proteins (the p200-proteins) encoded by the Ifi200-family genes share at least one partially conserved repeat of 200-amino acids (or HIN200 domain). Most proteins in the family also contain a homotypic protein-protein interaction pyrin domain (PYD). The PYD is often found in proteins that regulate a variety of physiologic responses, including cytokine responses and inflammation. The p200-family proteins mediate the biological and immunomodulatory activities of the IFNs.

Research Interest

autoimmunity, inflammation, systemic lupus erythematosus, lupus nephritis