Journal of Hepatology and Gastrointestinal disorders
Open Access

Ammonia level may NOT be associated with the severity of Hepatic Encephalopathy: An extensive Literature review

17^th International Conference on Gastroenterology and Hepatology

September 03-04, 2018 Dubai, UAE

Eyad Gadour

Fairfield General Hospital, UK

Posters & Accepted Abstracts: J Hepatol Gastroint Dis

Abstract :

Introduction: This literature provides a review regarding the value of checking ammonia level in hepatic Encephalopathy. The research examines the prognosis of Ammonia level in the blood, diagnosis and management of hepatic encephalopathy. Diagnosis of Hepatic Encephalopathy: The major clinical characteristics of diagnosis of hepatic Encephalopathy are depressed consciousness level, intellectual impairment and personality changes. During diagnosis, it is essential to detect signs suggesting hepatic encephalopathy among the patients suffering from liver disease and there is no clear indication of other causes to brain dysfunction. Thus, realization of precipitating factors indicated above supports hepatic encephalopathy diagnosis. The prognosis depends on the grade of liver failure, time of delivering effective treatment particularly precipitating factors and comorbidity. The progress of hepatic encephalopathy among patients with cirrhosis is correlated with a worse prediction and might cause frequent and elevated relapses. The patients with obvious hepatic encephalopathy in the hospitals have a 3.9% risk of increased mortality. Approximately 70% of having cirrhosis exhibit restrained symptoms of hepatic encephalopathy (1). These symptoms are likely to weaken patients. Obvious hepatic encephalopathy manifests in patients suffering from cirrhosis, and the approximate infection rate is 30 to 45%. About 25 to 53% port systemic shunt surgery patients exhibit the condition. Management of Hepatic Encephalopathy: The suitable management practices entail early diagnoses, aggressive identification of the precipitating factors and efforts to reduce severity (2). Evasion of some sedative drugs has been proposed as a key management practice. The main approaches suggested in include: checking the level of arterial ammonia during first evaluations in patients hospitalized due to impaired mental function and or cirrhosis. In stable outpatients, ammonia levels are low. Providing prophylactic endotracheal intubation to patients with grade 3 or grade 4 (severe encephalopathy) have aspiration risks in the intensive care unit (ICU). Lactulose and rifaximin use is useful but no superiority and can both be used if needed. Administration of low-protein diets in cirrhosis patients resulted in deteriorating of established protein-energy malnutrition. Thus, protein restriction is likely to help some patients with immediate effect after episodic hepatic encephalopathy. Certainly, malnutrition is regarded as a serious clinical problem compared to hepatic encephalopathy among the patients. Conclusion: Bloods ammonia mainly comes about due to the breakdown of the unabsorbed dietary protein by bacteria in the intestines. Among the hepatic encephalopathy, the levels of ammonia in the brain are higher compared to blood levels. High levels of ammonia in the blood may occur because of gastrointestinal bleeding, acute liver failure and chronic liver disease. The major reasons for testing ammonia levels in hepatic encephalopathy for patient who is presenting for the first time include: checking for success of treatment options, checking for liver condition following severe symptoms like excessive sleepiness and confusion, identifying disorders likely to cause brain damage, help in predicting outcomes from diagnoses carried out prognosis of hepatic encephalopathy, however, for patients who are known to have hepatic encephalopathy, in terms of recurrent admissions or previous diagnosis, checking ammonia is not routinely recommonded and carrying out the psychometric tests may be more useful. Keywords: Hepatic Encepahlopathy, Ammonia level, psychometric test, Lactulose and refaximin

Biography :

Eyad Gadour is currently senior specialist registrar in training program in Manchester-UK. He is about to become a Consultant Gastroenterologist with special interest in Hepatology and Hepatobiliary. His MBBS was obtained from The National Ribat University in Sudan. His General medicine training is conducted mainly in Manchester and done Fellowship in Inflammatory Bowel Disease IBD as well as Liver Transplantation at St James’s University Hospital in Leeds. Dr Gadour has publications in Gastroenterology, Hepatology as well as Upper GI Surgery with few international presentations.

E-mail: eyadgadour@doctors.org.uk