Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Xiaochun Yu, Juanjuan Xin, Junhong Gao, Yuanyuan Wang, FengYan Lu, Yuxue Zhao and Xianghong Jing
China Academy of Chinese Medical Sciences, China
Posters & Accepted Abstracts: J Clin Exp Cardiolog
Aim of this study is to investigate the effect of electro acupuncture (EA) at PC6 on the hypertension and myocardial hypertrophy in spontaneously hypertensive rats (SHRs). 30 SHRs were randomized into model, SHR+EA and SHR+sham EA group with WKY rats as normal control. EA was applied once a day in eight consecutive weeks. The blood pressure (BP), cardiac function and hypertrophy as well as the underlying mechanisms were investigated. After EA treatment, the enhanced BP in SHR+EA group was significantly lower than both before EA and model group. Echocardiographic, morphological studies showed that the enhanced anterior and posterior wall thickness (LVAWd and LVPWd), diameters and cross-sectional area (CSA) of cardiac myocyte, as well as the ratio of heart weight to body weight (HW/BW) were markedly diminished in SHR+EA group; while the reduced left ventricular ejection fraction, left ventricular short axis fraction shortening and E/A ratio were significantly ameliorated. The level of angiotensinconverting enzyme (ACE), angiotensin II type 1 and 2 receptors (AT1R, AT2R) in SHRs were also significantly attenuated by EA. The results suggested that EA at bilateral PC6 could arrest the hypertension development and ameliorate the cardiac hypertrophy and malfunction in SHRs, which might be mediated by the regulation of ACE, AT1R and AT2R.
Email: yuxc@mail.cintcm.ac.an